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. 2021 Feb;35(2):932-945.
doi: 10.1002/ptr.6846. Epub 2020 Nov 8.

The effect of geniposide on chronic unpredictable mild stress-induced depressive mice through BTK/TLR4/NF-κB and BDNF/TrkB signaling pathways

Tong Chen  1 , Shengnan Liu  1 , Menglin Zheng  1 , Yixuan Li  1 , Ling He  1
Affiliations

The effect of geniposide on chronic unpredictable mild stress-induced depressive mice through BTK/TLR4/NF-κB and BDNF/TrkB signaling pathways

Tong Chen et al. Phytother Res. 2021 Feb.

Abstract

The purpose of this study was to estimate the pharmacological effect of geniposide (GEN) on depression, caused by chronic unpredictable mild stress (CUMS), and explore its potential mechanism. During the 6 week CUMS procedure, the mice were treated with GEN (10, 40 mg/kg) by gavage once daily for 3 weeks. As a result, the GEN treatment remarkably improved the behavioral manifestations and suppressed the generations of inflammatory cytokines both in vivo and in vitro. The MDA level was significantly increased, while the activities of SOD, GSH-PX were decreased in CUMS-challenged mice and corticosterone-stimulated PC12 cells. GEN administration significantly inhibited those changes. Moreover, GEN treatment could downregulate the expressions of p-BTK, TLR4, MyD88, p-NF-κB proteins, and upregulate BDNF, p-TrkB generations in CUMS-induced mice. Moreover, GEN administration inhibited the protein levels of p-BTK, TLR4, MyD88, p-NF-κB in corticosterone-induced PC12 cell. In summary, the results suggested that GEN exerted a therapeutic effect on CUMS-induced depressive mice possibly through the regulation of BTK/TLR4/NF-κB and BDNF/TrkB signaling pathways.

Keywords: BDNF/TrkB pathway; BTK/TLR4/NF-κB pathway; CUMS; Geniposide; PC12 cells; depression.

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References

REFERENCES

    1. Bai, Y. Y., Ruan, C. S., Yang, C. R., Li, J. Y., Kang, Z. L., Zhou, L., … Zhou, X. F. (2016). ProBDNF signaling regulates depression-like behaviors in rodents under chronic stress. Neuropsychopharmacology, 41(12), 2882-2892.
    1. Bharti, V., Tan, H., Deol, J., Wu, Z., & Wang, J. F. (2020). Upregulation of antioxidant thioredoxin by antidepressants fluoxetine and venlafaxine. Psychopharmacology, 237(1), 127-136.
    1. Chu, C., Wei, H., Zhu, W., Shen, Y., & Xu, Q. (2017). Decreased prostaglandin D2 levels in major depressive disorder are associated with depression-like behaviors. The International Journal of Neuropsychopharmacology, 20(9), 731-739.
    1. Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., … Geddes, J. R. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. Lancet, 391(10128), 1357-1366.
    1. Colasanti, A., Guo, Q., Giannetti, P., Wall, M. B., Newbould, R. D., Bishop, C., … Rabiner, E. A. (2016). Hippocampal neuroinflammation, functional connectivity, and depressive symptoms in multiple sclerosis. Biological Psychiatry, 80(1), 62-72.