Diagnosis of pre-type I diabetes

J Pediatr. 1987 Dec;111(6 Pt 1):807-12. doi: 10.1016/s0022-3476(87)80192-0.


Islet cell antibodies were found in 71 of 1169 first-degree relatives (6.1%) from 448 families who had a proband with type I diabetes. Seven children have since become insulin dependent. All had islet cell antibodies and were followed up prospectively with measurement of first-phase insulin production during intravenous glucose tolerance testing. In this group the statistical probability of developing type I diabetes within 12 months with 95% confidence was found to be 59% to 100% when the first-phase insulin secretion was less than 25 microU/mL. The identification of the prediabetes time period should allow an opportunity for intervention in the underlying disease process to determine if the onset of type I diabetes can be altered.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies / analysis
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / immunology
  • Female
  • Follow-Up Studies
  • Humans
  • Islets of Langerhans / immunology
  • Male
  • Prediabetic State / diagnosis*
  • Prediabetic State / genetics
  • Prediabetic State / immunology
  • Prospective Studies


  • Antibodies