A Novel Case of Complement Factor B Deficiency

doi:10.1007/s10875-020-00906-3

Case Reports

. 2021 Jan;41(1):277-279.

doi: 10.1007/s10875-020-00906-3. Epub 2020 Nov 9.

A Novel Case of Complement Factor B Deficiency

Amélie Gauthier¹, Eric Wagner², Roseline Thibeault³, Aubert Lavoie⁴

Affiliations

¹ Department of Allergy and Immunology, CHU de Québec-CHUL, Laval University Hospital Center, Laval University, Quebec City, G1V 4G2, Canada. amelie.gauthier.1@ulaval.ca.
² Immunology and Histocompatibility Laboratory, CHU de Québec-Université Laval and Department of Microbiology-Infectiology and Immunology, Laval University, Quebec City, QC, G1V 4G2, Canada.
³ Department of Pediatrics, CHU de Québec-CHUL, Laval University, Quebec City, G1V 4G2, Canada.
⁴ Department of Allergy and Immunology, CHU de Québec-CHUL, Laval University Hospital Center, Laval University, Quebec City, G1V 4G2, Canada.

PMID: 33165708
DOI: 10.1007/s10875-020-00906-3

Case Reports

A Novel Case of Complement Factor B Deficiency

Amélie Gauthier et al. J Clin Immunol. 2021 Jan.

. 2021 Jan;41(1):277-279.

doi: 10.1007/s10875-020-00906-3. Epub 2020 Nov 9.

Authors

Amélie Gauthier¹, Eric Wagner², Roseline Thibeault³, Aubert Lavoie⁴

Affiliations

¹ Department of Allergy and Immunology, CHU de Québec-CHUL, Laval University Hospital Center, Laval University, Quebec City, G1V 4G2, Canada. amelie.gauthier.1@ulaval.ca.
² Immunology and Histocompatibility Laboratory, CHU de Québec-Université Laval and Department of Microbiology-Infectiology and Immunology, Laval University, Quebec City, QC, G1V 4G2, Canada.
³ Department of Pediatrics, CHU de Québec-CHUL, Laval University, Quebec City, G1V 4G2, Canada.
⁴ Department of Allergy and Immunology, CHU de Québec-CHUL, Laval University Hospital Center, Laval University, Quebec City, G1V 4G2, Canada.

PMID: 33165708
DOI: 10.1007/s10875-020-00906-3

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References

1. Audemard-Verger A, Descloux E, Ponard D, Deroux A, Fantin B, Fieschi C, et al. Infections revealing complement deficiency in adults a French nationwide study enrolling 41 patients. Medicine. 2016;95(19):e3548. - DOI
1. López-Lera A, Corvillo F, Nozal P, Regueiro JR, Sánchez-Corral P, López-Trascasa M. Complement as a diagnostic tool in immunopathology. Semin Cell Dev Biol. 2019;85:86–97. - DOI
1. Slade C, Bosco J, Unglik G, Bleasel K, Nagel M, Winship I. Deficiency in complement factor B. N Engl J Med. 2013;369(17):1667–9. - DOI
1. Tong HH, Li XY, Stahl GL, Thurman JM. Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2. Infect Immun. 2010;78(3):976–83. - DOI
1. Ponnuraj K, Xu Y, Macon K, Moore D, Volanakis JE, Narayana SV. Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. Mol Cell. 2004;14(1):17–28. - DOI

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[1] Audemard-Verger A, Descloux E, Ponard D, Deroux A, Fantin B, Fieschi C, et al. Infections revealing complement deficiency in adults a French nationwide study enrolling 41 patients. Medicine. 2016;95(19):e3548. - DOI

[2] Audemard-Verger A, Descloux E, Ponard D, Deroux A, Fantin B, Fieschi C, et al. Infections revealing complement deficiency in adults a French nationwide study enrolling 41 patients. Medicine. 2016;95(19):e3548. - DOI

[3] López-Lera A, Corvillo F, Nozal P, Regueiro JR, Sánchez-Corral P, López-Trascasa M. Complement as a diagnostic tool in immunopathology. Semin Cell Dev Biol. 2019;85:86–97. - DOI

[4] López-Lera A, Corvillo F, Nozal P, Regueiro JR, Sánchez-Corral P, López-Trascasa M. Complement as a diagnostic tool in immunopathology. Semin Cell Dev Biol. 2019;85:86–97. - DOI

[5] Slade C, Bosco J, Unglik G, Bleasel K, Nagel M, Winship I. Deficiency in complement factor B. N Engl J Med. 2013;369(17):1667–9. - DOI

[6] Slade C, Bosco J, Unglik G, Bleasel K, Nagel M, Winship I. Deficiency in complement factor B. N Engl J Med. 2013;369(17):1667–9. - DOI

[7] Tong HH, Li XY, Stahl GL, Thurman JM. Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2. Infect Immun. 2010;78(3):976–83. - DOI

[8] Tong HH, Li XY, Stahl GL, Thurman JM. Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2. Infect Immun. 2010;78(3):976–83. - DOI

[9] Ponnuraj K, Xu Y, Macon K, Moore D, Volanakis JE, Narayana SV. Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. Mol Cell. 2004;14(1):17–28. - DOI

[10] Ponnuraj K, Xu Y, Macon K, Moore D, Volanakis JE, Narayana SV. Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. Mol Cell. 2004;14(1):17–28. - DOI

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A Novel Case of Complement Factor B Deficiency

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