LPD-12: a promising lipopeptide to control COVID-19

Int J Antimicrob Agents. 2021 Jan;57(1):106218. doi: 10.1016/j.ijantimicag.2020.106218. Epub 2020 Nov 6.

Abstract

Introduction: The recent pandemic outbreak of SARS-CoV-2 has been associated with a lethal atypical pneumonia, making COVID-19 an urgent public health issue with an increasing rate of mortality and morbidity. There are currently no vaccines or therapeutics available for COVID-19, which is causing an urgent search for a new drug to combat the COVID-19 pandemic. The lipid membrane alternation efficiency of small antimicrobial lipopeptides enables them to block viral membrane fusion to the host cell. Lipopeptides could serve as potential antiviral agents, by interacting or competing with viral fusion proteins.

Methods: This study screened seven different lipopeptides (tsushimycin, daptomycin, surfactin, bacillomycin, iturin, srfTE, and LPD-12) and docked them individually against the spike (S)-glycoprotein of SARS-CoV-2.

Results: Based on the maximum docked score and minimum atomic contact energy, LPD-12 (-1137.38 kcal) was the appropriate molecule for proper binding with the S-glycoprotein of SARS-CoV-2 and thus significantly interrupted its affinity of binding with angiotensin-converting enzyme-2 (ACE2), which is the only receptor molecule found to be facilitating disease development. The results confirmed a strong binding affinity of LPD-12 with ACE2, with a binding free energy of -1621.62 kcal, which could also reciprocally prevent the binding of S-protein.

Conclustion: It can be concluded that LPD-12 may act as a potential therapeutic drug, by reducing the entry of SARS-CoV-2 to the human cells via the ACE2 receptor and related infections.

Keywords: COVID-19; Docking; Fusion protein; Lipopeptide; Novel coronavirus.

MeSH terms

  • Angiotensin-Converting Enzyme 2 / chemistry
  • Angiotensin-Converting Enzyme 2 / metabolism*
  • Antiviral Agents / chemistry
  • Antiviral Agents / metabolism*
  • Antiviral Agents / pharmacology
  • Drug Evaluation, Preclinical
  • Lipopeptides / chemistry*
  • Lipopeptides / pharmacology
  • Molecular Docking Simulation
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / metabolism
  • Spike Glycoprotein, Coronavirus / chemistry
  • Spike Glycoprotein, Coronavirus / metabolism*

Substances

  • Antiviral Agents
  • Lipopeptides
  • Peptides, Cyclic
  • Spike Glycoprotein, Coronavirus
  • lipopeptide detergent 12
  • spike protein, SARS-CoV-2
  • tsushimycin
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2