Antioxidant effects of N-acetylcysteine on the male reproductive system: A systematic review

Andrologia. 2021 Feb;53(1):e13898. doi: 10.1111/and.13898. Epub 2020 Nov 9.


This study aimed to evaluate the effect of N-acetyl cysteine on the male reproductive system and consensus and classification of data found from previous studies. It is undeniable that N-acetyl cysteine as a powerful antioxidant compound can medicate many diseases such as cardiovascular, kidney, liver and reproductive system disorders. With the increasing environmental pollution that has a direct adverse effect on male fertility, the use of this compound is able to positively function on human fertility health. In this study, we have been collected the main data of scientific articles (1994-2020) about N-acetyl cysteine effects. By searching in the scientific databases of PubMed, Google Scholar, Science Direct, Wiley and Web of Science, related articles were extracted. As a result, all observations have confirmed that N-acetyl cysteine can improve and normalise the spermatogenesis in the male reproduction system.

Keywords: N-acetylcysteine; fertility; oxidative stress; spermatogenesis; testicular tissue.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Acetylcysteine* / pharmacology
  • Antioxidants* / pharmacology
  • Genitalia, Male
  • Humans
  • Kidney
  • Male
  • Spermatogenesis


  • Antioxidants
  • Acetylcysteine