Background: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear.
Methods: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review.
Results: The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P- patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P- was 2.67 ± 0.58.
Conclusions: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.
Keywords: clinical significance; intraparotid lymph node metastasis; nodal metastasis; prevalence; primary parotid cancer; survival.
© 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.