Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate

Mol Cell Biol. 1987 Oct;7(10):3673-7. doi: 10.1128/mcb.7.10.3673-3677.1987.

Abstract

We have identified, cloned, and sequenced the gene for the small subunit of ribonucleotide diphosphate reductase of Saccharomyces cerevisiae. The protein and its transcript are induced about 10-fold by the alkylating agent methyl methanesulfonate, a result which suggests that the gene is induced by DNA damage.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • Cross Reactions
  • DNA Damage*
  • Gene Expression Regulation / drug effects*
  • Genes
  • Genes, Fungal
  • Methyl Methanesulfonate / pharmacology*
  • Molecular Sequence Data
  • Rec A Recombinases / genetics
  • Ribonucleotide Reductases / genetics*
  • Ribonucleotide Reductases / immunology
  • Saccharomyces cerevisiae / genetics*
  • Transcription, Genetic / drug effects

Substances

  • Methyl Methanesulfonate
  • Ribonucleotide Reductases
  • Rec A Recombinases

Associated data

  • GENBANK/M17789