Immunoregulatory properties of synthetic peptides, fragments of a proline-rich polypeptide (PRP) from ovine colostrum

Mol Immunol. 1987 Oct;24(10):1029-31. doi: 10.1016/0161-5890(87)90069-1.

Abstract

It has been previously found that a proline-rich polypeptide (PRP) isolated from ovine colostrum has a regulatory effect on the immune response. A nonapeptide fragment Val-Glu-Ser-Tyr-Val-Pro-Leu-Phe-Pro was isolated from the chymotryptic digest of PRP. The nonapeptide showed biological activity similar to PRP. The determined amino acid sequence was now confirmed by synthesis. Synthetic nonapeptide as well as its C-terminal hexapeptide, Tyr-Val-Pro-Leu-Phe-Pro, showed biological activity similar to PRP and the nonapeptide obtained from PRP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibody-Producing Cells / immunology
  • Colostrum / immunology*
  • Female
  • Hemolytic Plaque Technique
  • Mice
  • Mice, Inbred CBA
  • Peptide Fragments / chemical synthesis
  • Peptide Fragments / immunology*
  • Peptides / immunology*
  • Proline-Rich Protein Domains
  • Sheep

Substances

  • Peptide Fragments
  • Peptides