FGF23 and Cause-Specific Mortality in Community-Living Individuals-The Health, Aging, and Body Composition Study

J Am Geriatr Soc. 2021 Mar;69(3):711-717. doi: 10.1111/jgs.16910. Epub 2020 Nov 10.


Objectives: Fibroblast growth factor (FGF)-23 is a key regulator of mineral metabolism and has been linked with left ventricular hypertrophy in animal models. Most existing epidemiologic studies evaluated a C-terminal FGF23 assay which measures both the intact (active) hormone and inactive fragments. The relationship of intact FGF23 with cause-specific mortality is unknown.

Design: Prospective analyses of data from Health, Aging, & Body Composition (HABC) study.

Setting: Community-living adults aged 70 to 79 years with longitudinal follow up.

Keywords: FGF23; assays; cause-specific; mortality.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Aged
  • Aging
  • Biomarkers / blood
  • Cardiovascular Diseases / mortality
  • Cause of Death*
  • Female
  • Fibroblast Growth Factor-23
  • Fibroblast Growth Factors / blood*
  • Humans
  • Independent Living / statistics & numerical data
  • Male
  • Prospective Studies


  • Biomarkers
  • FGF23 protein, human
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23