Epigenetic silencing of HTLV-1 expression by the HBZ RNA through interference with the basal transcription machinery

Blood Adv. 2020 Nov 10;4(21):5574-5579. doi: 10.1182/bloodadvances.2020001675.

Abstract

  1. By disrupting basal transcription machinery, HBZ RNA inhibits sense transcription of human T-cell leukemia virus type 1.

  2. Repression of genomic expression may allow entry into proviral latency and escape from immune response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basic-Leucine Zipper Transcription Factors / genetics
  • Basic-Leucine Zipper Transcription Factors / metabolism
  • Epigenesis, Genetic
  • HTLV-I Infections*
  • Human T-lymphotropic virus 1* / genetics
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell*
  • RNA
  • Retroviridae Proteins / genetics
  • Retroviridae Proteins / metabolism

Substances

  • Basic-Leucine Zipper Transcription Factors
  • HBZ protein, human T-cell leukemia virus type I
  • Retroviridae Proteins
  • RNA