PD-L1 Blockade Therapy: Location, Location, Location

Cancer Cell. 2020 Nov 9;38(5):615-617. doi: 10.1016/j.ccell.2020.10.017.

Abstract

The mechanisms by which PD-1/PD-L1 inhibition elicits anti-tumor immunity are not fully understood. In this issue of Cancer Cell, Dammeijer et al. address the role of PD-L1 inhibition specifically within the tumor-draining lymph node, identifying a potential role for PD-L1 expressing dendritic cells within the lymph node in regulation of anti-tumor immune responses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • B7-H1 Antigen*
  • Cell Line, Tumor
  • Lymph Nodes
  • Programmed Cell Death 1 Receptor*
  • T-Lymphocytes

Substances

  • B7-H1 Antigen
  • Programmed Cell Death 1 Receptor