A rare case of Clostridium paraputrificum bacteremia in a 78-year-old Caucasian man diagnosed with an intestinal neoplasm

Anaerobe. 2020 Dec:66:102292. doi: 10.1016/j.anaerobe.2020.102292. Epub 2020 Nov 7.

Abstract

Clostridium like species, particularly Clostridium perfrigens, are the second most common causes of human anaerobic infections, including myonecrosis and bacteremia. Clostridium paraputrificum is an infrequent isolate, which has been identified in only 1% of reported cases of clostridial infections. We herein report a rare case of C. paraputrificum bacteremia in a 78-year-old Caucasian man diagnosed with an intestinal carcinoma and liver neoplastic lesions. The isolate was susceptible to chloramphenicol, meropenem, metronidazole, vancomycin, and resistant to clindamycin and penicillin, and the patient was successfully treated with metronidazole. Malignancy and inflammatory bowel diseases are often associated with clostridial bacteremia, which cannot be neglected.

Keywords: Bacteremia; Clostridium paraputrificum; Intestinal neoplasm; MALDI-TOF; Underlying medical conditions.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Bacteremia / diagnosis
  • Bacteremia / drug therapy
  • Bacteremia / microbiology
  • Clostridium / classification
  • Clostridium / drug effects
  • Clostridium / isolation & purification
  • Clostridium Infections / diagnosis*
  • Clostridium Infections / drug therapy
  • Clostridium Infections / microbiology*
  • Humans
  • Inflammatory Bowel Diseases / complications
  • Intestinal Neoplasms / complications
  • Male
  • Microbial Sensitivity Tests
  • Risk Factors
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents

Supplementary concepts

  • Clostridium paraputrificum