Electrophysiological responses of hamster suprachiasmatic neurones to neuropeptide Y in the hypothalamic slice preparation

Neurosci Lett. 1987 Sep 23;80(2):173-9. doi: 10.1016/0304-3940(87)90649-5.


The rate and pattern of neuronal discharge in the hamster suprachiasmatic nucleus (SCN) was studied using an in vitro hypothalamic slice preparation. The firing rate of hamster SCN neurones (n = 183 cells) exhibited a circadian variation similar to that reported in the rat. SCN neurones tested for responses to pressure ejection of neuropeptide Y (NPY) (n = 49) were either tonically excited (65%) or unresponsive (35%). There was a tendency for more NPY-responsive cells to be recorded during the light phase of the circadian light-dark cycle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Cricetinae
  • In Vitro Techniques
  • Male
  • Mesocricetus
  • Neuropeptide Y / pharmacology*
  • Suprachiasmatic Nucleus / drug effects
  • Suprachiasmatic Nucleus / physiology*


  • Neuropeptide Y