Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla
- PMID: 33172265
- PMCID: PMC8176626
- DOI: 10.1021/acs.jnatprod.0c00700
Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla
Abstract
During a chemical investigation of Wikstroemia scytophylla, three new [wikstrocins A-C (1-3)] and three known tigliane diterpenoids (4-6) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds (4 and 6) showed potent anti-HIV activity with IC50 values of 3.8 and 12.8 nM, respectively.
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References
-
- Kulkosky J; Culnan DM; Roman J; Dornadula G; Schnell M; Boyd MR; Pomerantz RJ Blood 2001, 98, 3006–3015. - PubMed
-
- Wu Z; Raven PH; Hong D. Flora of China; Science Press/Botanical Garden Press: Beijing, China/St. Louis, MO, 2007; Vol. 13.
-
- Guo J; Tian J; Yao G; Zhu H; Xue Y; Luo Z; Zhang J; Zhang Y; Zhang Y Fitoterapia 2015, 106, 242–246. - PubMed
-
- Dagang W; Sorg B; Adolf W; Opferkuch HJ; Seip EH; Hecker E Phytother. Res 1993, 7, 194–196.
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