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. 2020 Dec 24;83(12):3584-3590.
doi: 10.1021/acs.jnatprod.0c00700. Epub 2020 Nov 10.

Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla

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Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla

Kouharu Otsuki et al. J Nat Prod. .

Abstract

During a chemical investigation of Wikstroemia scytophylla, three new [wikstrocins A-C (1-3)] and three known tigliane diterpenoids (4-6) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds (4 and 6) showed potent anti-HIV activity with IC50 values of 3.8 and 12.8 nM, respectively.

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Figures

Figure 1.
Figure 1.
Structures of compounds 16.
Figure 2.
Figure 2.
1H–1H COSY and HMBC correlations of compounds 13.
Figure 3.
Figure 3.
ROESY correlations of compound 1 and NOESY correlations of 2 and 3.
Figure 4.
Figure 4.
UV (upper) and ECD (lower) spectra of compounds 16.

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