Editorial Commentary: Mesenchymal Stem Cell Preparation Methods Affect the Properties of Shoulder Subacromial Bursa-Derived Cells

Arthroscopy. 2020 Nov;36(11):2803-2804. doi: 10.1016/j.arthro.2020.08.002.


Augmentation of mesenchymal stem cells (MSCs) from the subacromial bursa in the setting of irreparable rotator cuff tears is a powerful candidate for future regenerative medicine. However, little is known about whether the preparation technique affects the individual differences and potentials of subacromial bursa-derived MSCs. The yields obtained by chopping or cell-expansion techniques with a high-density of initial nucleated cells seem to be lower than those obtained with low-density cell-expansion techniques. Differences in cell-preparation methods may affect whether individual differences in their properties exist. Further studies are required using a low-density cell-expansion technique to establish a new regenerative treatment using subacromial bursa-derived MSCs for irreparable rotator cuff tears.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Cell Proliferation
  • Demography
  • Humans
  • Mesenchymal Stem Cells*
  • Rotator Cuff Injuries* / surgery
  • Shoulder