Placental inflammasome signaling: Protection for mother and baby

J Exp Med. 2021 Jan 4;218(1):e20201738. doi: 10.1084/jem.20201738.


The second trimester of pregnancy is traditionally viewed as an immunosuppressive state. Megli et al. ( change this paradigm, showing that midgestation induces inflammasome signaling in placental trophoblasts to promote fetal and maternal antimicrobial defense. The placenta is thus a dynamic immunological organ.

Publication types

  • Comment

MeSH terms

  • Female
  • Fetus
  • Humans
  • Inflammasomes*
  • Mothers
  • Placenta*
  • Pregnancy
  • Trophoblasts


  • Inflammasomes