Totally laparoscopic versus open pancreaticoduodenectomy: A propensity score matching analysis of short-term outcomes

Eur J Surg Oncol. 2021 Mar;47(3 Pt B):674-680. doi: 10.1016/j.ejso.2020.10.036. Epub 2020 Nov 5.


Introduction: Laparoscopic pancreaticoduodenectomy (LPD) is a demanding operation that has not yet gained popularity. Safety, feasibility, and clinical advantages of LPD in comparison with open pancreaticoduodenectomy (OPD) have not been clearly demonstrated. The aim of this study was to compare the short term outcomes of LPD with those of OPD.

Material and methods: Data from a prospectively collected database of patients who underwent pancreaticoduodenectomy at our institution between January 2013 and March 2020 were retrieved and analyzed, comparing the short-term postoperative outcomes of LPD and OPD, using a propensity score matching analysis.

Results: In the study period, 177 patients undergoing pancreaticoduodenectomy were selected, 52 of these were LPD. In the LPD group, the conversion rate to OPD was 3.8%. After matching, a total of 50 LPD and 50 OPD were compared. LPD was associated with a shorter length of stay (14 vs 20 days, p = 0.011), decreased blood loss (255 vs 350 ml, p = 0.022), but longer median operative time (590 vs 382.5 min; p < 0.001). No significant difference was found between LPD and OPD in terms of overall complications (56% vs 62%, p = 0.542), severe complications (26% vs 22%, p = 0.640), and postoperative mortality (4% vs 6%, p = 0.646). The groups had similar reoperation rate, pancreatic-specific complications, and readmission rate.

Conclusions: In comparison with the open approach, LPD seems associated to with improved short-term outcomes in terms of hospital stay and blood loss, but with a longer operative time. No difference in morbidity and mortality rate were found in our series.

Keywords: Laparoscopic pancreaticoduodenectomy; Minimally invasive pancreaticoduodenectomy; Pancreatic cancer; Pancreatic surgery; Periampullary cancer.

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma / surgery*
  • Aged
  • Ampulla of Vater*
  • Blood Loss, Surgical / statistics & numerical data
  • Common Bile Duct Neoplasms / surgery*
  • Cystadenoma, Serous / surgery
  • Female
  • Humans
  • Intention to Treat Analysis
  • Laparoscopy / methods
  • Length of Stay / statistics & numerical data*
  • Male
  • Middle Aged
  • Mortality
  • Neuroendocrine Tumors / surgery*
  • Pancreatic Intraductal Neoplasms / surgery
  • Pancreatic Neoplasms / surgery*
  • Pancreaticoduodenectomy / methods*
  • Pancreatitis, Chronic / surgery
  • Postoperative Complications / epidemiology*
  • Propensity Score