Psychological aspects and fertility issues of GTD

Best Pract Res Clin Obstet Gynaecol. 2021 Jul:74:53-66. doi: 10.1016/j.bpobgyn.2020.10.007. Epub 2020 Oct 22.


Gestational trophoblastic disease (GTD) represents a spectrum of rare pregnancy-related disorders, including both premalignant and malignant entities. Although GTD's medical outcomes have been widely explored, limited data are available regarding the related psychological, sexual, and fertility issues. The present chapter aims to enhance comprehension of the psychosocial impact of GTD by discussing the main quantitative and qualitative evidence available in this field. Although patients globally report a good quality of life, clinically significant levels of anxiety and depression have been consistently found across studies. Similarly, despite the quality of couple relationships being generally satisfactory, they often complain of a lack of sexual desire. Moreover, pregnancy loss may raise significant and long-term fertility-related concerns. Specific socio-demographic and clinical factors have been identified as predictors of psychosocial outcomes. At the clinical level, research suggests that there is a need to provide multidisciplinary care to patients.

Keywords: Couple relationship; Fertility distress; Gestational trophoblastic disease; Quality of life; Sexual functioning.

Publication types

  • Review

MeSH terms

  • Anxiety / etiology
  • Female
  • Fertility
  • Gestational Trophoblastic Disease*
  • Humans
  • Infertility*
  • Pregnancy
  • Quality of Life