Redesigning nature's poisons to create anti-tumor reagents

Science. 1987 Nov 20;238(4830):1098-104. doi: 10.1126/science.3317828.


Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents
  • Clinical Trials as Topic
  • Humans
  • Immunotoxins* / pharmacokinetics
  • Immunotoxins* / toxicity
  • Neoplasms, Experimental / therapy
  • Recombinant Proteins / therapeutic use


  • Antineoplastic Agents
  • Immunotoxins
  • Recombinant Proteins