Systemic immune-inflammation index is a novel marker to predict functionally significant coronary artery stenosis

Biomark Med. 2020 Nov;14(16):1553-1561. doi: 10.2217/bmm-2020-0274. Epub 2020 Nov 12.


Aim: The study aimed to investigate and compare the predictive capacity of a systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) to determine a hemodynamically significant coronary artery stenosis assessed by fractional flow reserve (FFR). Patients & methods: A total of 207 chronic coronary syndrome patients with FFR measurement were enrolled in the study. NLR, PLR and SII levels were calculated. Results: The cut-off value of the SII (620) was associated with 78.4% sensitivity and 64.0% specificity to predict a hemodynamically significant stenosis. SII level independently predicted FFR ≤0.80. Conclusion: SII is an independent predictor of functionally significant coronary stenosis detected by FFR in chronic coronary syndrome patients. SII levels can predict hemodynamically severe obstruction better than NLR and PLR.

Keywords: coronary angiography; fractional flow reserve; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; systemic immune-inflammation index.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Biomarkers
  • Blood Platelets
  • Coronary Angiography
  • Coronary Stenosis / diagnosis*
  • Coronary Stenosis / immunology*
  • Coronary Stenosis / metabolism
  • Diagnostic Techniques, Cardiovascular
  • Female
  • Fractional Flow Reserve, Myocardial / immunology*
  • Fractional Flow Reserve, Myocardial / physiology
  • Humans
  • Inflammation
  • Lymphocyte Count
  • Lymphocytes
  • Male
  • Middle Aged
  • Neutrophils
  • Prognosis
  • Retrospective Studies


  • Biomarkers