Discussions on the quality of antibodies are no reason to ban animal immunization

doi:10.15252/embr.202051761

. 2020 Dec 3;21(12):e51761.

doi: 10.15252/embr.202051761. Epub 2020 Nov 12.

Discussions on the quality of antibodies are no reason to ban animal immunization

René Custers¹, Jan Steyaert^{2

3}

Affiliations

¹ VIB (Flanders Institute for Biotechnology), Ghent, Belgium.
² Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
³ VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.

PMID: 33179844
PMCID: PMC7726777
DOI: 10.15252/embr.202051761

Discussions on the quality of antibodies are no reason to ban animal immunization

René Custers et al. EMBO Rep. 2020.

. 2020 Dec 3;21(12):e51761.

doi: 10.15252/embr.202051761. Epub 2020 Nov 12.

Authors

René Custers¹, Jan Steyaert^{2

3}

Affiliations

¹ VIB (Flanders Institute for Biotechnology), Ghent, Belgium.
² Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
³ VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.

PMID: 33179844
PMCID: PMC7726777
DOI: 10.15252/embr.202051761

Abstract

Debates about the source of antibodies and their use are confusing two different issues. A ban on life immunization would have no repercussions on the quality of antibodies.

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Conflict of interest statement

Jan Steyaert runs Nanobodies4Instruct, a flagship platform of Instruct‐ERIC that is part of the European Strategy Forum on Research Infrastructures (ESFRI). This facility focusses on the discovery of Nanobodies to be used in Structural Biology. He is also founder and senior advisor of ConfoTherapeutics.

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References

1. Bradbury A, Pluckthun A (2015) Standardize antibodies used in research. Nature 518: 27–29 - PubMed
1. Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M et al (2018) When monoclonal antibodies are not monospecific: hybridomas frequently express additional functional variable regions. Mabs 10: 539–546 - PMC - PubMed
1. EURL ECVAM (2020) Recommendation on non‐animal‐derived antibodies, joint research center science for policy report, EUR 20185 EN. doi: 10.2760/80554 - DOI
1. Gray A (2020) Antibody production to bypass animals. Nature 581: 262 - PubMed
1. Gray AC, Bradbury ARM, Knappik A, Plückthun A, Borrebaeck CAK, Dübel S (2020) Animal‐derived‐antibody generation faces strict reform in accordance with European Union policy on animal use. Nat Methods 17: 755–756 - PubMed

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[1] Bradbury A, Pluckthun A (2015) Standardize antibodies used in research. Nature 518: 27–29 - PubMed

[2] Bradbury A, Pluckthun A (2015) Standardize antibodies used in research. Nature 518: 27–29 - PubMed

[3] Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M et al (2018) When monoclonal antibodies are not monospecific: hybridomas frequently express additional functional variable regions. Mabs 10: 539–546 - PMC - PubMed

[4] Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M et al (2018) When monoclonal antibodies are not monospecific: hybridomas frequently express additional functional variable regions. Mabs 10: 539–546 - PMC - PubMed

[5] EURL ECVAM (2020) Recommendation on non‐animal‐derived antibodies, joint research center science for policy report, EUR 20185 EN. doi: 10.2760/80554 - DOI

[6] EURL ECVAM (2020) Recommendation on non‐animal‐derived antibodies, joint research center science for policy report, EUR 20185 EN. doi: 10.2760/80554 - DOI

[7] Gray A (2020) Antibody production to bypass animals. Nature 581: 262 - PubMed

[8] Gray A (2020) Antibody production to bypass animals. Nature 581: 262 - PubMed

[9] Gray AC, Bradbury ARM, Knappik A, Plückthun A, Borrebaeck CAK, Dübel S (2020) Animal‐derived‐antibody generation faces strict reform in accordance with European Union policy on animal use. Nat Methods 17: 755–756 - PubMed

[10] Gray AC, Bradbury ARM, Knappik A, Plückthun A, Borrebaeck CAK, Dübel S (2020) Animal‐derived‐antibody generation faces strict reform in accordance with European Union policy on animal use. Nat Methods 17: 755–756 - PubMed

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Discussions on the quality of antibodies are no reason to ban animal immunization

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Discussions on the quality of antibodies are no reason to ban animal immunization

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Abstract

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