New insights into the function of mammalian Argonaute2

PLoS Genet. 2020 Nov 12;16(11):e1009058. doi: 10.1371/journal.pgen.1009058. eCollection 2020 Nov.

Abstract

Uncovering the mechanisms that recognise a microRNA (miRNA) target is 1 of the biggest challenges because the Ago-miRNA complex is able to overcome different derogations of complementarity when binding targets. However, the recently solved crystallographic structure of Argonaute2 (Ago2) and a high-throughput analysis that used repurposed sequencing techniques has brought us closer to achieving this goal.

Publication types

  • Review

MeSH terms

  • Animals
  • Argonaute Proteins / genetics*
  • Argonaute Proteins / metabolism*
  • Argonaute Proteins / physiology
  • Humans
  • Mammals / genetics
  • Mammals / metabolism
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • RNA, Guide, CRISPR-Cas Systems
  • RNA, Messenger / genetics

Substances

  • AGO2 protein, human
  • Argonaute Proteins
  • MicroRNAs
  • RNA, Messenger

Grants and funding

The author received no specific funding for this work.