Abstract
Uncovering the mechanisms that recognise a microRNA (miRNA) target is 1 of the biggest challenges because the Ago-miRNA complex is able to overcome different derogations of complementarity when binding targets. However, the recently solved crystallographic structure of Argonaute2 (Ago2) and a high-throughput analysis that used repurposed sequencing techniques has brought us closer to achieving this goal.
MeSH terms
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Animals
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Argonaute Proteins / genetics*
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Argonaute Proteins / metabolism*
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Argonaute Proteins / physiology
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Humans
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Mammals / genetics
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Mammals / metabolism
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MicroRNAs / genetics
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MicroRNAs / metabolism
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RNA, Guide, CRISPR-Cas Systems
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RNA, Messenger / genetics
Substances
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AGO2 protein, human
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Argonaute Proteins
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MicroRNAs
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RNA, Messenger
Grants and funding
The author received no specific funding for this work.