Newcomers in Vascular Anomalies

Surg Pathol Clin. 2020 Dec;13(4):719-728. doi: 10.1016/j.path.2020.08.008.


Vascular anomalies are composed of tumors and malformations and with overlapping histologies, thus are often misdiagnosed or labeled with imprecise terminology. Lesions are common and usually diagnosed during infancy or childhood; the estimated prevalence is 4.5%. Vascular tumors rapidly enlarge postnatally and demonstrate endothelial proliferation. Malformations are errors in vascular development with stable endothelial turnover; they are typically named based on the primary vessel that is malformed (capillary, arterial, venous, lymphatic). This article reviews the pathologic and molecular genetic characteristics for select recently described vascular anomalies.

Keywords: FAVA; Hemangioma; Lymphangiomatosis; Overgrowth; PROS; Vascular anomalies.

Publication types

  • Review

MeSH terms

  • Child
  • Humans
  • Prognosis
  • Vascular Malformations / classification
  • Vascular Malformations / diagnosis
  • Vascular Malformations / pathology*
  • Vascular Malformations / therapy
  • Vascular Neoplasms / classification
  • Vascular Neoplasms / diagnosis
  • Vascular Neoplasms / pathology*
  • Vascular Neoplasms / therapy