Vitamin D and sleep duration: Is there a bidirectional relationship?

Horm Mol Biol Clin Investig. 2020 Nov 13;41(4). doi: 10.1515/hmbci-2020-0025.


Vitamin D contributes to numerous physiological processes within the body but primarily calcium and bone homeostasis. Emerging evidence highlights a novel role for vitamin D in maintaining and regulating optimal sleep. Sleep is a known regulator of bone health, highlighting the interconnectedness between vitamin D concentrations, sleep duration and bone metabolism. It is possible that the relationship between sleep length and vitamin D is bidirectional, with vitamin D playing a role in sleep health and conversely, sleep affecting vitamin D levels. Nevertheless, limited information on the direction of the interaction is available, and much remains to be learned concerning the complex relationship between insufficient sleep duration and vitamin D deficiency. Given the potential to implement interventions to improve sleep and vitamin D supplementation, understanding this relationship further could represent a novel way to support and improve health.

Keywords: bone metabolism; sleep duration; vitamin D.

MeSH terms

  • Biomarkers
  • Bone and Bones / metabolism
  • Dietary Supplements
  • Disease Susceptibility
  • Humans
  • Sleep / physiology*
  • Sleep Wake Disorders / etiology
  • Sleep Wake Disorders / metabolism
  • Vitamin D / metabolism*
  • Vitamin D Deficiency / complications
  • Vitamin D Deficiency / metabolism


  • Biomarkers
  • Vitamin D