SnapShot: APC/T Cell Immune Checkpoints

Scott H Shrager; Christina Kiel

doi:10.1016/j.cell.2020.10.007

SnapShot: APC/T Cell Immune Checkpoints

Cell. 2020 Nov 12;183(4):1142-1142.e1. doi: 10.1016/j.cell.2020.10.007.

Authors

Scott H Shrager¹, Christina Kiel¹

Affiliation

¹ Systems Biology Ireland and UCD Charles Institute of Dermatology, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.

PMID: 33186524
DOI: 10.1016/j.cell.2020.10.007

Abstract

Immune checkpoints are key regulatory mechanisms integral to the maintenance of self-tolerance and execution of antigen-specific immune responses. In recent years, they have been leveraged to treat both autoimmune disease and various forms of cancer with much success. This SnapShot illustrates known immune checkpoint interactions in APC-mediated T cell modulation. To view this SnapShot, open or download the PDF.

MeSH terms

Antigen-Presenting Cells / drug effects
Antigen-Presenting Cells / immunology*
Humans
Immune Checkpoint Inhibitors / pharmacology
Immune Checkpoint Proteins / chemistry
Immune Checkpoint Proteins / metabolism*
Protein Domains
Protein Interaction Maps
T-Lymphocytes / drug effects
T-Lymphocytes / immunology*

Substances

Immune Checkpoint Inhibitors
Immune Checkpoint Proteins