Sodium restriction can delay the return of hypertension in patients previously well-controlled on drug therapy

Can J Physiol Pharmacol. 1987 Aug;65(8):1752-5. doi: 10.1139/y87-274.


Sodium restriction can reduce blood pressure in hypertensive patients. The present study indicates that if hypertension is well controlled then the reemergence of hypertension can be decreased by the use of a reduced sodium intake. The present paper demonstrates that in such patients on a normal salt diet, 90% become hypertensive within 6 months while only 40% of people on a reduced sodium diet become hypertensive. It is proposed that a high sodium intake activates a number of amplifiers that causes a shift of the dose-response curve to sodium to the left and if not prevented or interrupted leads to the development of hypertension.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Benzothiadiazines
  • Blood Pressure
  • Clinical Trials as Topic
  • Diet, Sodium-Restricted*
  • Diuretics
  • Humans
  • Hypertension / diet therapy*
  • Hypertension / drug therapy
  • Male
  • Middle Aged
  • Posture
  • Random Allocation
  • Sodium / urine
  • Sodium Chloride Symporter Inhibitors / therapeutic use


  • Benzothiadiazines
  • Diuretics
  • Sodium Chloride Symporter Inhibitors
  • Sodium