Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 18:14:565114.
doi: 10.3389/fnhum.2020.565114. eCollection 2020.

Neural Correlates of Repetition Priming: A Coordinate-Based Meta-Analysis of fMRI Studies

Sung-Mu Lee  1   2 , Richard N Henson  2   3 , Chun-Yu Lin  1   4
Affiliations

Neural Correlates of Repetition Priming: A Coordinate-Based Meta-Analysis of fMRI Studies

Sung-Mu Lee et al. Front Hum Neurosci. .

Abstract

Repetition priming is a form of implicit memory, whereby classification or identification of a stimulus is improved by prior presentation of the same stimulus. Repetition priming is accompanied with a deceased fMRI signal for primed vs. unprimed stimuli in various brain regions, often called "repetition suppression," or RS. Previous studies proposed that RS in posterior regions is associated with priming of perceptual processes, whereas RS in more anterior (prefrontal) regions is associated with priming of conceptual processes. To clarify which regions exhibit reliable RS associated with perceptual and conceptual priming, we conducted a quantitative meta-analysis using coordinate-based activation likelihood estimation. This analysis included 65 fMRI studies that (i) employed visual repetition priming during either perceptual or conceptual tasks, (ii) demonstrated behavioral priming, and (iii) reported the results from whole-brain analyses. Our results showed that repetition priming was mainly associated with RS in left inferior frontal gyrus and fusiform gyrus. Importantly, RS in these regions was found for both perceptual and conceptual tasks, and no regions show RS that was selective to one of these tasks. These results question the simple distinction between conceptual and perceptual priming, and suggest consideration of other factors such as stimulus-response bindings.

Keywords: conceptual; fMRI; meta-analysis; perceptual; repetition priming; stimulus-response bindings.

PubMed Disclaimer

Figures

Figure 1
Figure 1
PRISMA flow chart for procedure of study selection.
Figure 2
Figure 2
Brain regions showing the occurrences of RS (red) and RE (green) from an ALE meta-analysis of all priming experiments.
Figure 3
Figure 3
Brain regions showing the occurrences of repetition suppression from an ALE meta-analysis of the conceptual (red) and perceptual (green) priming experiments.
Figure 4
Figure 4
Results of conjunction analysis. Brain regions showing RS for both conceptual and perceptual priming.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ballesteros S., Bischof G. N., Goh J. O., Park D. C. (2013). Neural correlates of conceptual object priming in young and older adults: an event-related functional magnetic resonance imaging study. Neurobiol. Aging 34, 1254–1264. 10.1016/j.neurobiolaging.2012.09.019 - DOI - PMC - PubMed
    1. Bergerbest D., Gabrieli J. D. E., Whitfield-Gabrieli S., Kim H., Stebbins G. T., Bennett D. A., et al. . (2009). Age-associated reduction of asymmetry in prefrontal function and preservation of conceptual repetition priming. Neuroimage 45, 237–246. 10.1016/j.neuroimage.2008.10.019 - DOI - PMC - PubMed
    1. Blaxton T. A. (1989). Investigating dissociations among memory measures: Support for a transfer-appropriate processing framework. J. Exp. Psychol. 15, 657–668. 10.1037/0278-7393.15.4.657 - DOI
    1. Blaxton T. A. (1999). Combining disruption and activation techniques to map conceptual and perceptual memory processes in the human brain, in Memory: Structure, Function, or Process? eds Foster J. K., Jelicic M. (Oxford: Oxford University Press; ), 104–129.
    1. Brooks S. J., Savov V., Allzén E., Benedict C., Fredriksson R., Schiöth H. B. (2012). Exposure to subliminal arousing stimuli induces robust activation in the amygdala, hippocampus, anterior cingulate, insular cortex and primary visual cortex: a systematic meta-analysis of fMRI studies. Neuroimage 59, 2962–2973. 10.1016/j.neuroimage.2011.09.077 - DOI - PubMed

Publication types

LinkOut - more resources