Analysis of 22 immunomodulatory substances for efficacy in low-dose streptozotocin-induced diabetes

Diabetes Res. 1987 Sep;6(1):21-7.

Abstract

Of 22 immunomodulatory substances screened 12 were effective in modulating the course of hyperglycemia following low dose streptozotocin treatment. In this animal model diabetes is induced by administration of low doses of streptozotocin (30-40 mg/kg) body weight to male C57BL/6J/Bom, C57BL/KsJ and C3H/He/Bom mice on 5 consecutive days. Conventional immunosuppressants (azathioprine, cyclophosphamide) largely protected from diabetes development. Partial suppression of hyperglycemia was also seen after administration of B. pertussis, fetal tissue extracts, FTS, inosine pranobex, metronidazole and ADA 202-718. The majority of these substances, when applied with another regimen, and TP5 caused enhancement of diabetes. In conclusion, several substances with a therapeutic potential in experimental diabetes have been identified. Those with little risk of side-effects may deserve further analysis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Azathioprine / pharmacology
  • Blood Glucose / metabolism
  • Cell- and Tissue-Based Therapy
  • Cyclophosphamide / pharmacology
  • Diabetes Mellitus, Experimental / immunology*
  • Diabetes Mellitus, Experimental / prevention & control
  • Immunosuppressive Agents / pharmacology*
  • Islets of Langerhans / immunology
  • Male
  • Mice
  • Mice, Inbred Strains
  • Pertussis Vaccine / pharmacology

Substances

  • Adjuvants, Immunologic
  • Blood Glucose
  • Immunosuppressive Agents
  • Pertussis Vaccine
  • Cyclophosphamide
  • Azathioprine