Effects of feeding lactobacillus GG on lethal irradiation in mice

Diagn Microbiol Infect Dis. 1987 May;7(1):1-7. doi: 10.1016/0732-8893(87)90063-0.


Mice exposed to 1400 rads of total body irradiation experienced 80%-100% mortality in 2 wk. Bacteremia was demonstrated in all dead animals. Feeding Lactobacillus GG strain reduced Pseudomonas bacteremia and prolonged survival time in animals colonized with this organism. In animals not colonized with Pseudomonas, feeding Lactobacillus GG also produced some reduction in early deaths, and there was less Gram-negative bacteremia in these animals compared with controls.

MeSH terms

  • Animals
  • Female
  • Humans
  • Intestines / microbiology*
  • Lactobacillus / growth & development*
  • Lactobacillus / isolation & purification
  • Mice
  • Pseudomonas Infections / physiopathology
  • Radiation Protection*
  • Sepsis / physiopathology*
  • Whole-Body Irradiation