Observation and Control of Gene Expression Noise: Barrier Crossing Analogies Between Drug Resistance and Metastasis

Front Genet. 2020 Oct 30;11:586726. doi: 10.3389/fgene.2020.586726. eCollection 2020.

Authors

Michael Tyler Guinn^{1

2

3}, Yiming Wan^{1

2}, Sarah Levovitz^{1

2}, Dongbo Yang⁴, Marsha R Rosner⁴, Gábor Balázsi^{1

2}

Affiliations

¹ Biomedical Engineering Department, Stony Brook University, Stony Brook, NY, United States.
² Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, United States.
³ Stony Brook Medical Scientist Training Program, Stony Brook, NY, United States.
⁴ Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, United States.

No abstract available

Keywords: cancer; control; drug resistance; metastasis; noise; non-genetic heterogeneity; synthetic biology.

Grant support