Complete response of penile mycosis fungoides with systemic brentuximab therapy

Urol Case Rep. 2020 Oct 21;34:101460. doi: 10.1016/j.eucr.2020.101460. eCollection 2021 Jan.


Mycosis fungoides with penile involvement is extremely rare. Previous reports have shown successful treatment with imiquimod or a combination of beam radiation and chemotherapy. We present a patient with mycosis fungoides and penile involvement. The penile lesions were initially treated with topical imiquimod; however, he developed worsening glandular lesions and discharge. Therefore the treatment was discontinued. Subsequent treatment with brentuximab (anti-CD30) targeted therapy resulted in complete resolution of the penile lesions. To our knowledge, this represents the first case of a complete penile mycosis fungoides response to brentuximab therapy. Brentuximab may be considered for refractory penile mycoses fungoides.

Keywords: Anti-CD30; Brentuximab; Imiquimod; Mycosis fungoides; Remission.

Publication types

  • Case Reports