Case 284: Posterior Quadrantic Dysplasia

Radiology. 2020 Dec;297(3):733-737. doi: 10.1148/radiol.2020190726.


History A 36-year-old left-handed woman with a history of developmental delay and medical refractory seizures since birth most recently presented with continuous simple partial seizures and occasional breakthrough complex partial seizures with postictal migraines. These were described as the patient "becoming pale with sinking to the floor and staring for approximately 1 minute with confusion thereafter." The patient had years of reported seizure freedom until 2010 when she was evaluated for intractable headaches, and electroencephalography revealed her focal subclinical status. At that time, ambulatory electroencephalography findings showed asymmetric left parietal-occipital high-amplitude spike-and-wave discharges in her best awake and alert state. Since that time, the patient developed and continues to have complex partial seizures every 2-3 months that are persistent despite the implementation of several medical regimens. At the time of recent presentation, the patient initially underwent unenhanced head CT in the emergency department followed by unenhanced MRI of the brain due to increased seizure activity at the patient's group home despite continued compliance with her antiepileptic regimen. Contrast material-enhanced imaging was not available at the time of recent presentation, so comparison was made with gadolinium-enhanced brain MRI performed approximately 9 years earlier.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Contrast Media
  • Electroencephalography
  • Epilepsy / diagnostic imaging*
  • Epilepsy / etiology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Malformations of Cortical Development / complications
  • Malformations of Cortical Development / diagnostic imaging*
  • Tomography, X-Ray Computed


  • Contrast Media