Effect of Antibiotic Use Within First 48 Hours of Life on the Preterm Infant Microbiome: A Randomized Clinical Trial

JAMA Pediatr. 2021 Mar 1;175(3):303-305. doi: 10.1001/jamapediatrics.2020.4916.


This randomized clinical trial investigates whether withholding the standard 48 hours of intravenous empirical antibiotics immediately after birth in preterm infants protects the developing microbiome and improves clinical outcomes.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / adverse effects
  • Disease Models, Animal
  • Gastrointestinal Microbiome / drug effects*
  • Germ-Free Life / drug effects
  • Infant, Premature / metabolism*
  • Mice


  • Anti-Bacterial Agents