Drug Induced Cutaneous Manifestations due to Treatment of Gastrointestinal Disorders

Curr Drug Metab. 2021;22(2):99-107. doi: 10.2174/1389200221999201116143109.


Cutaneous manifestations due to drugs used in the treatment of gastrointestinal disorders are multiple and common. Adequate diagnosis is of great importance, bearing in mind that the therapeutic regimen depends on its diagnosis. In this review, we provided an overview of the most common drug-induced skin lesions with a detailed explanation of the disease course, presentation and treatment, having in mind that in recent years, novel therapeutic modalities have been introduced in the treatment of various gastrointestinal disorders, and that incidence of cutaneous adverse reactions has been on the rise.

Keywords: Drug reactions; SJS; TEN; acneiform eruptions; angioedema; drug-induced pemphigus; erythroderma; fixed drug reactions; gastrointestinal disorders; serum sickness like; urticaria; vasculitis.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Gastrointestinal Agents / adverse effects*
  • Gastrointestinal Agents / classification
  • Gastrointestinal Agents / pharmacology
  • Gastrointestinal Diseases / drug therapy*
  • Humans
  • Skin Diseases* / chemically induced
  • Skin Diseases* / classification
  • Skin Diseases* / diagnosis
  • Skin Diseases* / therapy


  • Gastrointestinal Agents