Mucosal immunity and tRNA, tRF, and tiRNA

doi:10.1007/s00109-020-02008-4

Review

. 2021 Jan;99(1):47-56.

doi: 10.1007/s00109-020-02008-4. Epub 2020 Nov 16.

Mucosal immunity and tRNA, tRF, and tiRNA

Yueying Chen^{1

2

3}, Jun Shen^{4

5

6}

Affiliations

¹ Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, 160# Pu Jian Ave, Shanghai, 200127, China.
² Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160# Pu Jian Ave, Shanghai, 200127, China.
³ Shanghai Institute of Digestive Disease, 160# Pu Jian Ave, Shanghai, 200127, China.
⁴ Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, 160# Pu Jian Ave, Shanghai, 200127, China. shenjun_renji@163.com.
⁵ Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160# Pu Jian Ave, Shanghai, 200127, China. shenjun_renji@163.com.
⁶ Shanghai Institute of Digestive Disease, 160# Pu Jian Ave, Shanghai, 200127, China. shenjun_renji@163.com.

PMID: 33200232
DOI: 10.1007/s00109-020-02008-4

Review

Mucosal immunity and tRNA, tRF, and tiRNA

Yueying Chen et al. J Mol Med (Berl). 2021 Jan.

. 2021 Jan;99(1):47-56.

doi: 10.1007/s00109-020-02008-4. Epub 2020 Nov 16.

Authors

Yueying Chen^{1

2

3}, Jun Shen^{4

5

6}

Affiliations

¹ Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, 160# Pu Jian Ave, Shanghai, 200127, China.
² Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160# Pu Jian Ave, Shanghai, 200127, China.
³ Shanghai Institute of Digestive Disease, 160# Pu Jian Ave, Shanghai, 200127, China.
⁴ Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, 160# Pu Jian Ave, Shanghai, 200127, China. shenjun_renji@163.com.
⁵ Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160# Pu Jian Ave, Shanghai, 200127, China. shenjun_renji@163.com.
⁶ Shanghai Institute of Digestive Disease, 160# Pu Jian Ave, Shanghai, 200127, China. shenjun_renji@163.com.

PMID: 33200232
DOI: 10.1007/s00109-020-02008-4

Abstract

Mucosal immunity has crucial roles in human diseases such as respiratory tract infection, inflammatory bowel diseases (IBD), and colorectal cancer (CRC). Recent studies suggest that the mononuclear phagocyte system, cancer cells, bacteria, and viruses induce the mucosal immune reaction by various pathways, and can be major factors in the pathogenesis of these diseases. Transfer RNA (tRNA) and its fragments, including tRNA-derived RNA fragments (tRFs) and tRNA-derived stress-induced RNAs (tiRNAs), have emerged as a hot topic in recent years. They not only are verified as essential for transcription and translation but also play roles in cellular homeostasis and functions, such as cell metastasis, proliferation, and apoptosis. However, the specific relationship between their biological regulation and mucosal immunity remains unclear to date. In the present review, we carry out a comprehensive discussion on the specific roles of tRNA, tRFs, and tiRNAs relevant to mucosal immunity and related diseases.

Keywords: Mucosal immunity; Transfer RNA (tRNA); tRNA-derived RNA fragments (tRFs); tRNA-derived stress-induced RNAs (tiRNAs).

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References

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[1] Bamias G, Arseneau KO, Cominelli F (2017) Mouse models of inflammatory bowel disease for investigating mucosal immunity in the intestine. Curr Opin Gastroenterol 33:411–416 - PubMed

[2] Bamias G, Arseneau KO, Cominelli F (2017) Mouse models of inflammatory bowel disease for investigating mucosal immunity in the intestine. Curr Opin Gastroenterol 33:411–416 - PubMed

[3] Silva FA, Rodrigues BL, Ayrizono ML, Leal RF (2016) The immunological basis of inflammatory bowel disease. Gastroenterol Res Pract 2016:2097274 - PubMed - PMC

[4] Silva FA, Rodrigues BL, Ayrizono ML, Leal RF (2016) The immunological basis of inflammatory bowel disease. Gastroenterol Res Pract 2016:2097274 - PubMed - PMC

[5] Hanauer SB (2006) Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflamm Bowel Dis 12(Suppl 1):S3–S9 - PubMed

[6] Hanauer SB (2006) Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflamm Bowel Dis 12(Suppl 1):S3–S9 - PubMed

[7] Cho J, Kim S, Yang DH, Lee J, Park KW, Go J, Hyun CL, Jee Y, Kang KS (2018) Mucosal immunity related to FOXP3(+) regulatory T cells, Th17 cells and cytokines in pediatric inflammatory bowel disease. J Korean Med Sci 33:e336 - PubMed - PMC

[8] Cho J, Kim S, Yang DH, Lee J, Park KW, Go J, Hyun CL, Jee Y, Kang KS (2018) Mucosal immunity related to FOXP3(+) regulatory T cells, Th17 cells and cytokines in pediatric inflammatory bowel disease. J Korean Med Sci 33:e336 - PubMed - PMC

[9] Yang J, Lim SY, Ko YS, Lee HY, Oh SW, Kim MG, Cho WY, Jo SK (2019) Intestinal barrier disruption and dysregulated mucosal immunity contribute to kidney fibrosis in chronic kidney disease. Nephrol Dial Transplant 34:419–428 - PubMed

[10] Yang J, Lim SY, Ko YS, Lee HY, Oh SW, Kim MG, Cho WY, Jo SK (2019) Intestinal barrier disruption and dysregulated mucosal immunity contribute to kidney fibrosis in chronic kidney disease. Nephrol Dial Transplant 34:419–428 - PubMed

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Mucosal immunity and tRNA, tRF, and tiRNA

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Mucosal immunity and tRNA, tRF, and tiRNA

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