Preparation and application of chitosan biomaterials in dentistry

Int J Biol Macromol. 2021 Jan 15:167:1198-1210. doi: 10.1016/j.ijbiomac.2020.11.073. Epub 2020 Nov 14.

Abstract

Chitosan is a biodegradable and biocompatible natural polysaccharide that has a wide range of applications in the field of dentistry due to its functional versatility and ease of access. Recent studies find that chitosan and its derivatives can be embedded in materials for dental adhesives, barrier membranes, bone replacement, tissue regeneration, and antimicrobial agent to better manage oral diseases. In this paper, we provide a comprehensive overview on the preparation, applications, and major breakthroughs of chitosan biomaterials. Furthermore, incorporation of chitosan additives for the modification and improvement of dental materials has been discussed in depth to promote more advanced chitosan-related research in the future.

Keywords: Biomaterials; Chitosan; Oral disease.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / pharmacology
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry*
  • Chitosan / chemistry*
  • Dentistry / methods*
  • Endodontics / methods
  • Humans
  • Periodontics / methods
  • Preventive Dentistry / methods
  • Prostheses and Implants
  • Prosthodontics / methods
  • Stomatognathic Diseases
  • Surgery, Oral / methods
  • Tissue Engineering / methods*
  • Wound Healing

Substances

  • Anti-Infective Agents
  • Biocompatible Materials
  • Chitosan