Radiation-induced skin injury: pathogenesis, treatment, and management

doi:10.18632/aging.103932

Review

. 2020 Nov 16;12(22):23379-23393.

doi: 10.18632/aging.103932. Epub 2020 Nov 16.

Radiation-induced skin injury: pathogenesis, treatment, and management

Xiaojing Yang¹, Hanru Ren², Xiaomao Guo^{3

4}, Chaosu Hu^{3

5}, Jie Fu¹

Affiliations

¹ Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China.
² Department of Orthopedics, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai, China.
³ Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
⁴ Shanghai Medical College, Fudan University, Shanghai, China.
⁵ Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

PMID: 33202382
PMCID: PMC7746368
DOI: 10.18632/aging.103932

Free PMC article

Review

Radiation-induced skin injury: pathogenesis, treatment, and management

Xiaojing Yang et al. Aging (Albany NY). 2020.

Free PMC article

. 2020 Nov 16;12(22):23379-23393.

doi: 10.18632/aging.103932. Epub 2020 Nov 16.

Authors

Xiaojing Yang¹, Hanru Ren², Xiaomao Guo^{3

4}, Chaosu Hu^{3

5}, Jie Fu¹

Affiliations

¹ Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China.
² Department of Orthopedics, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai, China.
³ Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
⁴ Shanghai Medical College, Fudan University, Shanghai, China.
⁵ Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

PMID: 33202382
PMCID: PMC7746368
DOI: 10.18632/aging.103932

Abstract

Radiation-induced skin injury (RSI) refers to a frequently occurring complication of radiation therapy. Nearly 90% of patients having received radiation therapy underwent moderate-to-severe skin reactions, severely reducing patients' quality of life and adversely affecting their disease treatment. No gold standard has been formulated for RSIs. In the present study, the mechanism of RSI and topical medications was discussed. Besides, this study can be referenced for clinicians to treat RSIs to guide subsequent clinical medicine.

Keywords: radiation; skin injury.

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Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare no conflicts of interest.

Figures

**Figure 1**
**Schematic diagram of related molecular mechanisms that may be involved in RSI.**

See this image and copyright information in PMC

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References

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[1] Brand RM, Epperly MW, Stottlemyer JM, Skoda EM, Gao X, Li S, Huq S, Wipf P, Kagan VE, Greenberger JS, Falo LD Jr. A topical mitochondria-targeted redox-cycling nitroxide mitigates oxidative stress-induced skin damage. J Invest Dermatol. 2017; 137:576–86. 10.1016/j.jid.2016.09.033 - DOI - PMC - PubMed

[2] Brand RM, Epperly MW, Stottlemyer JM, Skoda EM, Gao X, Li S, Huq S, Wipf P, Kagan VE, Greenberger JS, Falo LD Jr. A topical mitochondria-targeted redox-cycling nitroxide mitigates oxidative stress-induced skin damage. J Invest Dermatol. 2017; 137:576–86. 10.1016/j.jid.2016.09.033 - DOI - PMC - PubMed

[3] Nystedt KE, Hill JE, Mitchell AM, Goodwin F, Rowe LA, Wong FL, Kind AL. The standardization of radiation skin care in British Columbia: a collaborative approach. Oncol Nurs Forum. 2005; 32:1199–205. 10.1188/05.ONF.1199-1205 - DOI - PubMed

[4] Nystedt KE, Hill JE, Mitchell AM, Goodwin F, Rowe LA, Wong FL, Kind AL. The standardization of radiation skin care in British Columbia: a collaborative approach. Oncol Nurs Forum. 2005; 32:1199–205. 10.1188/05.ONF.1199-1205 - DOI - PubMed

[5] Hymes SR, Strom EA, Fife C. Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. J Am Acad Dermatol. 2006; 54:28–46. 10.1016/j.jaad.2005.08.054 - DOI - PubMed

[6] Hymes SR, Strom EA, Fife C. Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. J Am Acad Dermatol. 2006; 54:28–46. 10.1016/j.jaad.2005.08.054 - DOI - PubMed

[7] Martin MT, Vulin A, Hendry JH. Human epidermal stem cells: role in adverse skin reactions and carcinogenesis from radiation. Mutat Res. 2016; 770:349–68. 10.1016/j.mrrev.2016.08.004 - DOI - PubMed

[8] Martin MT, Vulin A, Hendry JH. Human epidermal stem cells: role in adverse skin reactions and carcinogenesis from radiation. Mutat Res. 2016; 770:349–68. 10.1016/j.mrrev.2016.08.004 - DOI - PubMed

[9] Zhang Y, Zhang S, Shao X. Topical agent therapy for prevention and treatment of radiodermatitis: a meta-analysis. Support Care Cancer. 2013; 21:1025–31. 10.1007/s00520-012-1622-5 - DOI - PubMed

[10] Zhang Y, Zhang S, Shao X. Topical agent therapy for prevention and treatment of radiodermatitis: a meta-analysis. Support Care Cancer. 2013; 21:1025–31. 10.1007/s00520-012-1622-5 - DOI - PubMed

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Radiation-induced skin injury: pathogenesis, treatment, and management

Affiliations

Radiation-induced skin injury: pathogenesis, treatment, and management

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