Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals

Molecules. 2020 Nov 13;25(22):5287. doi: 10.3390/molecules25225287.


The carrot plant (Daucus carota) and its components are traditionally reported for the management of gastric ulcers. This study was performed to evaluate the role of carrot when administered concurrently with a conventional antiulcer treatment, pantoprazole, in alleviating gastric and duodenal ulcers in female experimental animals. The study involved standard animal models to determine the ulcer preventive effect using pylorus ligation, ethanol, and stress induced acute gastric ulcer models and duodenal ulcer models involving cysteamine. Acetic acid-induced chronic gastric ulcer and indomethacin-induced gastric ulcer models were used to evaluate the ulcer healing effect. Carrot fruit (500 mg/kg) and its co-administration with pantoprazole produced significant protection in an ethanol- and stress-induced acute gastric ulcer and cysteamine-induced duodenal ulcer. The healing of the acetic acid-induced chronic gastric ulcer was also augmented with this combination. Both total proteins and mucin contents were significantly increased in indomethacin-induced gastric ulcers. Similarly, in pylorus ligation, the pepsin content of gastric juice, total acidity, and free acidity were reduced. Overall, both ulcer preventive effects and ulcer healing properties of the pantoprazole were significantly enhanced in animals who received the co-administration of carrot fruit (500 mg/kg).

Keywords: duodenal ulcer; gastric acid; gastric cytoprotection; gastric secretion; mucin.

MeSH terms

  • Acetic Acid / chemistry
  • Animals
  • Anti-Ulcer Agents / administration & dosage*
  • Antioxidants / pharmacology
  • Biphenyl Compounds / chemistry
  • Cysteamine / chemistry
  • Daucus carota / chemistry*
  • Drug Synergism
  • Ethanol / chemistry
  • Female
  • Free Radical Scavengers / chemistry
  • Indomethacin / adverse effects*
  • Inhibitory Concentration 50
  • Pantoprazole / administration & dosage*
  • Pepsin A / chemistry
  • Picrates / chemistry
  • Plant Preparations / administration & dosage*
  • Pylorus / drug effects*
  • Rats
  • Rats, Wistar


  • Anti-Ulcer Agents
  • Antioxidants
  • Biphenyl Compounds
  • Free Radical Scavengers
  • Picrates
  • Plant Preparations
  • Ethanol
  • Cysteamine
  • Pantoprazole
  • 1,1-diphenyl-2-picrylhydrazyl
  • Pepsin A
  • Acetic Acid
  • Indomethacin