Review of clinical applications of radiation-enhancing nanoparticles

N Scher; S Bonvalot; C Le Tourneau; E Chajon; C Verry; J Thariat; V Calugaru

doi:10.1016/j.btre.2020.e00548

Review of clinical applications of radiation-enhancing nanoparticles

Biotechnol Rep (Amst). 2020 Oct 28:28:e00548. doi: 10.1016/j.btre.2020.e00548. eCollection 2020 Dec.

Authors

N Scher¹, S Bonvalot², C Le Tourneau^{3

4

5}, E Chajon⁶, C Verry^{7

8}, J Thariat⁹, V Calugaru¹

Affiliations

¹ Department of Radiation Oncology, Institut Curie, Paris, France.
² Department of Surgery, PSL University, Institute Curie, Paris, France.
³ Department of Drug Development and Innovation (D3i), Institut Curie, Paris & Saint-Cloud, France.
⁴ INSERM U900 Research Unit, Saint-Cloud, France.
⁵ Paris-Saclay University, Paris, France.
⁶ Department of Radiotherapy. Eugène Marquis Cancer Center, Rennes, France.
⁷ Grenoble Alpes University Hospital, Department of Radiotherapy 38043 Grenoble, France.
⁸ Rayonnement Synchrotron Pour la Recherche Médicale (STROBE), Université Grenoble Alpes, Inserm UA7, 71 Rue des Martyrs, 38000 Grenoble, France.
⁹ Department of Radiotherapy, François Baclesse Centre, 3 Rue Du Général Harris, 14000, Caen, France.

Abstract

Purpose: Clinical evidence of the radiation-enhancing effects of nanoparticles has emerged.

Materials and methods: We searched the literature in English and French on PubMed up to October 2019. The search term was "nanoparticle" AND "radiotherapy", yielding 1270 results.

Results: The two main NP used in clinical trials were hafnium oxide and gadolinium involving a total of 229 patients. Hafnium oxide NP were used in three phase 1/2 trials on sarcoma, head and neck squamous cell carcinoma or liver cancer and one phase 2/3 trial. There are six ongoing phase 1/2 clinical trials to evaluate the combination of gadolinium-based NP and RT for the treatment of brain metastases and cervical cancer.

Conclusion: So far, intratumoral hafnium oxide nanoparticles were safe and improved efficacy in locally advanced sarcoma.

Keywords: Cancer; Nanoparticles; Radiotherapy.

Publication types

Review