"Chronic Disseminated Aspergillosis," a Novel Fungal Immune Reconstitution Inflammatory Syndrome

Annabelle Pourbaix; Romain Guery; Julie Bruneau; Estelle Blanc; Gregory Jouvion; Marthe Weinandt; Claire Rouzaud; Jérémy Lourenço; David Boutboul; Jean-Paul Mira; Alexandre Rouquette; Thierry Jo Molina; Marc Lecuit; Olivier Lortholary

doi:10.1093/ofid/ofaa175

"Chronic Disseminated Aspergillosis," a Novel Fungal Immune Reconstitution Inflammatory Syndrome

Open Forum Infect Dis. 2020 Nov 7;7(11):ofaa175. doi: 10.1093/ofid/ofaa175. eCollection 2020 Nov.

Authors

Annabelle Pourbaix¹, Romain Guery¹, Julie Bruneau², Estelle Blanc³, Gregory Jouvion^{4

5}, Marthe Weinandt⁶, Claire Rouzaud¹, Jérémy Lourenço¹, David Boutboul⁷, Jean-Paul Mira⁸, Alexandre Rouquette⁹, Thierry Jo Molina², Marc Lecuit^{1

10}, Olivier Lortholary^{1

11}

Affiliations

¹ Paris University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants Malades Hospital, AP-HP, Paris, France.
² Pathology Department, Necker-Enfants Malades Hospital, AP-HP, Paris Descartes University, Paris, France.
³ Nuclear Medicine Department, Marie Lannelongue Hospital, Le Plessis-Robinson, France.
⁴ Pathophysiology of Pediatric Genetic Diseases, Sorbonne Université, INSERM, Assistance Publique Hôpitaux de Paris, Hôpital Armand-Trousseau, UF Génétique Moléculaire, Paris, France.
⁵ Experimental Neuropathology Unit, Institut Pasteur, Paris, France.
⁶ Visceral Surgery Department, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France.
⁷ Clinical Immunopathology Department, St Louis Hospital, AP-HP, University of Paris, INSERM U967 HIPI, Paris, France.
⁸ Medical Intensive Care Department, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France.
⁹ Pathology Department, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France.
¹⁰ Biology of Infection Unit, Institut Pasteur, INSERM U1117, Paris, France.
¹¹ Molecular Mycology Unit, Institut Pasteur, CNRS UMR2000, Paris, France.

Abstract

We report a case of chronic hepatosplenic aspergillosis following immune reconstitution complicating colic aspergillosis in an AIDS patient with multicentric Castleman disease. Symptoms mimicked the clinical presentation of chronic disseminated candidiasis and responded to corticosteroid. This emerging entity enlarges the spectrum of fungal immune reconstitution inflammatory syndrome in the HIV setting.

Keywords: aspergillosis; hepatosplenic; immune reconstitution inflammatory syndrome.