HTLV-2 infection in Manaus, Brazil: first description of HTLV-2c subtype in an urban area of the Western Amazon region

Rev Soc Bras Med Trop. 2020 Nov 13;54:e20200066. doi: 10.1590/0037-8682-0066-2020. eCollection 2020.


Introduction: We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil.

Methods: Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region.

Results: A 29-year-old male carrier of sickle cell anemia with a history of multiple blood transfusions was diagnosed with the HTLV-2c subtype.

Conclusions: This study describes the first known occurrence of HTLV-2c in the urban area of Brazil's western Amazon region.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brazil / epidemiology
  • HTLV-I Infections* / diagnosis
  • HTLV-I Infections* / epidemiology
  • HTLV-II Infections* / diagnosis
  • HTLV-II Infections* / epidemiology
  • Human T-lymphotropic virus 1* / genetics
  • Human T-lymphotropic virus 2 / genetics
  • Humans
  • Male
  • Phylogeny