Foxp3 Re-distributes Its Heavy Lifting

Immunity. 2020 Nov 17;53(5):895-897. doi: 10.1016/j.immuni.2020.10.021.


Understanding the mechanisms that establish regulatory T (Treg) cell identity is central to understanding Treg cell function. van der Veeken et al. now show that the lineage-determining transcription factor Foxp3 establishes Treg-cell-specific chromatin architecture indirectly, mostly by decreasing the expression of other transcriptional regulators, including TCF1.

Publication types

  • Comment

MeSH terms

  • Chromatin
  • Forkhead Transcription Factors* / genetics
  • Forkhead Transcription Factors* / metabolism
  • Gene Expression Regulation
  • Lifting
  • T-Lymphocytes, Regulatory* / metabolism


  • Chromatin
  • Forkhead Transcription Factors