Organoid-based modeling of intestinal development, regeneration, and repair

Cell Death Differ. 2021 Jan;28(1):95-107. doi: 10.1038/s41418-020-00665-z. Epub 2020 Nov 18.

Abstract

The intestinal epithelium harbors a remarkable adaptability to undergo injury-induced repair. A key part of the regenerative response is the transient reprogramming of epithelial cells into a fetal-like state, which drives uniform proliferation, tissue remodeling, and subsequent restoration of the homeostatic state. In this review, we discuss how Wnt and YAP signaling pathways control the intestinal repair response and the transitioning of cell states, in comparison with the process of intestinal development. Furthermore, we highlight how organoid-based applications have contributed to the characterization of the mechanistic principles and key players that guide these developmental and regenerative events.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Animals
  • Epithelial Cells / metabolism*
  • Homeostasis
  • Humans
  • Intestinal Mucosa / metabolism
  • Intestines / cytology*
  • Intestines / physiology
  • Organoids / cytology
  • Organoids / metabolism*
  • Regeneration / physiology*
  • Wnt Signaling Pathway
  • YAP-Signaling Proteins

Substances

  • YAP-Signaling Proteins