Hypothetical Proteins as Predecessors of Long Non-coding RNAs

Curr Genomics. 2020 Nov;21(7):531-535. doi: 10.2174/1389202921999200611155418.

Abstract

Hypothetical Proteins [HP] are the transcripts predicted to be expressed in an organism, but no evidence of it exists in gene banks. On the other hand, long non-coding RNAs [lncRNAs] are the transcripts that might be present in the 5' UTR or intergenic regions of the genes whose lengths are above 200 bases. With the known unknown [KU] regions in the genomes rapidly existing in gene banks, there is a need to understand the role of open reading frames in the context of annotation. In this commentary, we emphasize that HPs could indeed be the predecessors of lncRNAs.

Keywords: Hypothetical proteins; annotation; aptamers; functional genomics; lncRNA; transcripts.

Publication types

  • Review