Recent Advances and Current Role of Transperineal Prostate Biopsy

Urol Clin North Am. 2021 Feb;48(1):25-33. doi: 10.1016/j.ucl.2020.09.010.


"Approximately 1 million prostate biopsies are performed each year in the United States. This procedure has traditionally been performed using a transrectal approach, which is associated with a significant risk of infectious complications including sepsis. In recent years, transperineal prostate biopsy has been increasingly adopted due to its lower associated infectious risk. In this review, we explore the benefits of the transperineal approach for performing prostate biopsy and detail technical advancements that have allowed for this procedure to now be routinely performed in the outpatient settings under local anesthesia."

Keywords: Infection; MRI; Prostate cancer; Robot-assisted; Sepsis; Transperineal prostate biopsy; Transrectal prostate biopsy; Transrectal ultrasound.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Bacterial Infections / etiology
  • Bacterial Infections / prevention & control
  • Biopsy / adverse effects
  • Biopsy / methods*
  • Biopsy / trends
  • Humans
  • Image-Guided Biopsy / adverse effects
  • Image-Guided Biopsy / methods*
  • Image-Guided Biopsy / trends
  • Magnetic Resonance Imaging
  • Male
  • Perineum / surgery
  • Prostate / pathology*
  • Prostate / surgery
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / surgery
  • Rectum / surgery
  • Robotic Surgical Procedures / methods
  • Robotic Surgical Procedures / trends
  • Ultrasonography