[Effects of intravenous administration of memantine in parkinsonian patients (author's transl)]

Arzneimittelforschung. 1977 Jul;27(7):1487-9.
[Article in German]


After a preliminary study in 6 parkinsonian patients concerning the effectiveness and tolerance of 1,3-dimethyl-5-aminoadamantane hydrochloride (memantine) an investigation to assess its short-term effects was performed. In an unselected group of 12 parkinsonian patients 40 mg of memantine diluted in 500 ml of laevulose were applied i.v. within 2 h. The patients were examined under standardized conditions before, immediately after and 2, 4 and 24 h, respectively, using a program of physchological tests. The results give evidence for a favourable influence on rigor and tremor in Parkinson's syndrome as well as on motor drive. In comparative studies memantine showed a better tolerance than adamantylaminosulfate. The short-time effects of the drug could be differentiated from placebo and learning effects.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Amantadine / adverse effects
  • Amantadine / analogs & derivatives*
  • Amantadine / therapeutic use
  • Clinical Trials as Topic
  • Female
  • Humans
  • Infusions, Parenteral
  • Male
  • Memantine / administration & dosage
  • Memantine / adverse effects
  • Memantine / therapeutic use*
  • Middle Aged
  • Parkinson Disease / drug therapy*
  • Placebos
  • Time Factors


  • Placebos
  • Amantadine
  • Memantine