Therapeutic potential of nutraceuticals to protect brain after stroke

Neurochem Int. 2021 Jan:142:104908. doi: 10.1016/j.neuint.2020.104908. Epub 2020 Nov 19.


Stroke leads to significant neuronal death and long-term neurological disability due to synergistic pathogenic mechanisms. Stroke induces a change in eating habits and in many cases, leads to undernutrition that aggravates the post-stroke pathology. Proper nutritional regimen remains a major strategy to control the modifiable risk factors for cardiovascular and cerebrovascular diseases including stroke. Studies indicate that nutraceuticals (isolated and concentrated form of high-potency natural bioactive substances present in dietary nutritional components) can act as prophylactic as well as adjuvant therapeutic agents to prevent stroke risk, to promote ischemic tolerance and to reduce post-stroke consequences. Nutraceuticals are also thought to regulate blood pressure, delay neurodegeneration and improve overall vascular health. Nutraceuticals potentially mediate these effects by their powerful antioxidant and anti-inflammatory properties. This review discusses the studies that have highlighted the translational potential of nutraceuticals as stroke therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Antioxidants / administration & dosage
  • Brain / metabolism*
  • Brain / pathology
  • Cerebrovascular Disorders / diet therapy
  • Cerebrovascular Disorders / metabolism
  • Cerebrovascular Disorders / prevention & control
  • Dietary Supplements*
  • Humans
  • Neuroprotection / physiology*
  • Stroke / diet therapy*
  • Stroke / metabolism*
  • Stroke / pathology


  • Anti-Inflammatory Agents
  • Antioxidants