Intraarterial Chemotherapy for Liver Metastases

Surg Oncol Clin N Am. 2021 Jan;30(1):143-158. doi: 10.1016/j.soc.2020.08.005. Epub 2020 Oct 20.

Abstract

Colorectal cancer (CRC) is one of the leading cancers globally in terms of both incidence and cancer-related mortality. Liver metastatic disease is the main prognostic driver for patients with CRC. The management options for liver metastatic CRC continue to evolve, particularly with the incorporation of locoregional therapies into the treatment paradigm. Hepatic arterial infusion (HAI) chemotherapy is one such liver directed approach used with the goal of converting patients to liver resection, reducing the risk of recurrence, treating recurrent disease, and most importantly improving overall survival. This article summarizes the role of HAI chemotherapy in the treatment of liver metastatic CRC.

Keywords: Colorectal cancer; Conversion to resection; Hepatic arterial infusion chemotherapy; Intrahepatic cholangiocarcinoma; Survival.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols
  • Colorectal Neoplasms* / drug therapy
  • Colorectal Neoplasms* / surgery
  • Fluorouracil / therapeutic use
  • Hepatectomy
  • Hepatic Artery
  • Humans
  • Infusions, Intra-Arterial
  • Liver Neoplasms* / drug therapy
  • Liver Neoplasms* / surgery

Substances

  • Fluorouracil