The Problem of Neurovascular Uncoupling

Shruti Agarwal; Haris I Sair; Jay J Pillai

doi:10.1016/j.nic.2020.09.003

The Problem of Neurovascular Uncoupling

Neuroimaging Clin N Am. 2021 Feb;31(1):53-67. doi: 10.1016/j.nic.2020.09.003. Epub 2020 Oct 29.

Authors

Shruti Agarwal¹, Haris I Sair², Jay J Pillai³

Affiliations

¹ Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.
² Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA; The Malone Center for Engineering in Healthcare, The Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
³ Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA. Electronic address: jpillai1@jhmi.edu.

PMID: 33220828
DOI: 10.1016/j.nic.2020.09.003

Abstract

Neurovascular uncoupling (NVU) is one of the most important confounds of blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMR imaging) in the setting of focal brain lesions such as brain tumors. This article reviews the assessment of NVU related to focal brain lesions with emphasis on the use of cerebrovascular reactivity mapping measurement methods and resting state BOLD fMR imaging metrics in the detection of NVU, as well as the use of amplitude of low-frequency fluctuation metrics to mitigate the effects of NVU on clinical fMR imaging activation.

Keywords: Motor activation; Neurovascular uncoupling; Presurgical mapping.

Publication types

Review

MeSH terms

Brain / diagnostic imaging
Brain / physiopathology
Brain / surgery
Brain Mapping / methods*
Brain Neoplasms / diagnostic imaging*
Brain Neoplasms / physiopathology*
Brain Neoplasms / surgery
Humans
Magnetic Resonance Imaging / methods*
Neurovascular Coupling / physiology*
Preoperative Care / methods*