Dynamic Brain Connectivity in Resting State Functional MR Imaging

Rozita Jalilianhasanpour; Daniel Ryan; Shruti Agarwal; Elham Beheshtian; Sachin K Gujar; Jay J Pillai; Haris I Sair

doi:10.1016/j.nic.2020.09.004

Dynamic Brain Connectivity in Resting State Functional MR Imaging

Neuroimaging Clin N Am. 2021 Feb;31(1):81-92. doi: 10.1016/j.nic.2020.09.004. Epub 2020 Nov 2.

Authors

Rozita Jalilianhasanpour¹, Daniel Ryan¹, Shruti Agarwal¹, Elham Beheshtian¹, Sachin K Gujar¹, Jay J Pillai², Haris I Sair³

Affiliations

¹ Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.
² Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA.
³ Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA; The Malone Center for Engineering in Healthcare, The Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA. Electronic address: hsair1@jhmi.edu.

PMID: 33220830
DOI: 10.1016/j.nic.2020.09.004

Abstract

Dynamic functional connectivity adds another dimension to resting-state functional MR imaging analysis. In recent years, dynamic functional connectivity has been increasingly used in resting-state functional MR imaging, and several studies have demonstrated that dynamic functional connectivity patterns correlate with different physiologic and pathologic brain states. In fact, evidence suggests that dynamic functional connectivity is a more sensitive marker than static functional connectivity; therefore, it might be a promising tool to add to clinical functional neuroimaging. This article provides a broad overview of dynamic functional connectivity and reviews its general principles, techniques, and potential clinical applications.

Keywords: Brain mapping; Dynamic connectivity; Functional connectivity; Resting state MR imaging; Rs-fMRI.

Publication types

Review

MeSH terms

Brain / diagnostic imaging
Brain Diseases / diagnostic imaging*
Brain Mapping / methods*
Humans
Magnetic Resonance Imaging / methods*
Rest